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Image Search Results
Journal: Nature Communications
Article Title: MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters
doi: 10.1038/s41467-023-40108-0
Figure Lengend Snippet: a Reduced transcription start site (TSS) enrichment score (y axis) in MOF cKO epithelial cells when compared with those of control cells. Ctrl_Epi, control epithelial cells, MOF cKO_Epi, MOF cKO epithelial cells. b Reduced normalized Tn5 insertion profile calculated from scATACseq data for MOF target genes in MOF cKO. c Unchanged normalized Tn5 insertion profile calculated from scATACseq data for epithelial marker genes, which are not targeted by MOF. d Integrative Genomics Viewer (IGV) browser view for two mitochondrial genes showing MOF binding on their promoters and reduced promoter openness in MOF cKO epithelial cells determined by scATACseq. e IGV browser view of Sfta1 with non-changed promoter openness in MOF cKO epithelial cells determined by scATACseq. f Schematic illustration of MOF/H4K16ac-regulated gene expression controlling mouse skin morphogenesis through regulating mitochondria and primary cilia. Created with BioRender.com.
Article Snippet: Mouse reference dataset for
Techniques: Control, Marker, Binding Assay, Gene Expression